Genomics Range
Beckman Coulter GenomeLab GeXP Genetic Analysis System
The single best multiplex solution for quantitative, high-throughput, cost-effective gene expression analysis. more>


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Genomics



Sciex GeXP Genetic Analysis System
The single best multiplex solution for quantitative, high-throughput, cost-effective gene expression analysis.

Finally, quantitative gene expression that's cost-effective too. The GenomeLab™ GeXP Genetic Analysis System utilizes a patented, highly multiplexed PCR* approach to quickly and efficiently look at the expression of multiplexed gene sets with greater sensitivity and speed. Building on more than a decade of innovative leadership in laboratory automation and capillary electrophoresis technology, the GenomeLab GeXP clears your pathway to discovery.

Multiple applications for gene expression
  • Discovery of Gene Targets
  • Pathway Analysis
  • Biomarker Discovery
  • Microarray Data Validation
  • RNAi Studies
  • Drug Characterization
  • Development of Signatures
  • Monitor Gene Regulation 

Beckman Coulter’s preformulated, ready-to-use GenomeLab GeXP Reagent Kits are optimized for effortless and robust quantitative gene expression. The kits include reagents for discovery, master mix reagents for multiplexing user-defined genes and GenomLab GeXP multiplex kits for performing quantitative gene expression studies on human, mouse or rat genes.

High-throughput quantitative gene expression.
With a capacity to analyze up to 30 genes/reaction, the scalable GenomeLab GeXP enables the monitoring of tens to hundreds of genes for up to tens of thousands of samples. A capacity that is unmatched by other methods in the industry.
Cost-effective gene expression.
By lowering PCR expenses and improving efficiency, the multiplex power built into the GenomeLab GeXP enables you to analyze up to 30 genes/sample at a dramatically reduced cost per sample.
Low sample requirement.
With this super-sensitive gene expression technology, microarray discoveries can be translated into high-throughput assays with good correlation between multiplexed PCR and microarray data. Coupled with capillary electrophoresis readout, this method can be efficiently used to look at focused sets of genes using very small amounts of total RNA (5ng total RNA/reaction), or varied quality of RNA.
 
The GenomeLab GeXP is flexible enough to adapt to a broad spectrum of applications, yet easily accessible to a wide range of users. This system provides high-quality DNA sequencing and high-precision fragment sizing, with sophisticated software algorithms. The GeXP software automatically analyzes quality and highlights results that need further review, allowing you to rapidly assess and interpret your data.
  • De Novo DNA Sequencing
  • Heterozygote Detection
  • Confirmatory Sequencing
  • Mutation Analysis
  • Allele Identification
  • SNP Scoring
  • Microsatellite Instability
  • AFLP® Fingerprinting
  • Gene Expression
Applications
Since the first publication of the DNA double helical structure, electrophoresis has been a standard among the analytical tools used for nucleic acid analysis. Capillary electrophoresis (CE) technology extends the power of electrophoresis by using a format that incorporates direct detection, automation and the ability to study interactions in solution.
The following applications are routinely performed on the Beckman Coulter CE-based Genetic analysis systems.
  • CEQ™ Series Applications (Capillary array technology)
    Dye Terminator Cycle Sequencing     
    • Automated Heterozygote Detection 
    • Automated Fragment Sizing and Allele Identification 
    • Short Tandem Repeat (STR) Analysis 
    • Single Nucleotide Polymorphisms (SNP) 
    • Amplified Fragment Length Polymorphisms 
    • Quantitation / Loss of Heterozygosity 
    • Automated Generation of Locus Tags - Binning 

 
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